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Expert's Guide To Breaking Down Acetaldehyde

Acetaldehyde breakdown guide by getsunset.com


We at SRQ Labs have spent over a decade researching the effect that acetaldehyde has on the human body and have consulted with experts worldwide about how to best aid the body in breaking it down.

Our primary goal in breaking down acetaldehyde has been specific to when the toxin enters the body during the metabolism of alcohol, however exposure to this toxin is not restricted to alcohol consumption alone.

It is also important to highlight that not all people are affected by acetaldehyde equally.  A large proportion of the world’s population possess a genetic deficiency in an enzyme called ALDH2 that reduces their ability to break down this toxin.  This deficiency is apparent if a person gets a red face when they drink alcohol and is most common in people of Asian origin.

The purpose of this article is to raise awareness about acetaldehyde and critique the various methods people are currently using to help their body break it down.

What is Acetaldehyde?

Acetaldehyde

Acetaldehyde is a flammable liquid that is commonly used in the manufacture of acetic acid, perfumes, and flavors.[1]   It is also found in varying concentrations in plants, fresh fruits, vegetables, cigarette smoke, gasoline and diesel exhaust fumes.[2]

In addition to the above-mentioned sources, our bodies also encounter the toxin during the metabolism of alcohol.  Acetaldehyde is produced via the action of alcohol dehydrogenase on ethanol and is often stated to be a lot more toxic than ethanol itself.[3]

Sources of Acetaldehyde

In order to help break down acetaldehyde, it is important to know how it is getting into the body.  Here are some common ways that acetaldehyde makes its way from the environment into the human body:  

Acetaldehyde from Alcohol

As mentioned above, acetaldehyde produced by the action of alcohol dehydrogenase when we consume alcohol.

Alcohol dehydrogenases are a class of enzymes that play an important role in the oxidation and reduction of various aldehydes such as acetaldehyde. These enzymes occur in large numbers in the liver and play an important role in metabolising the alcohol that we consume.[4]

breaking down acetaldehyde from alcohol

They do this by breaking apart the alcohol molecule to allow the body to more easily eliminate it. Firstly, alcohol dehydrogenase enzymes convert the alcohol to acetaldehyde. Then the acetaldehyde is further broken down into a less toxic byproduct called acetate.  The acetate is then easily converted into water and carbon dioxide for easy elimination by the body.[5]

Acetaldehyde from Smoking

Tobacco smoke has been shown to contain acetaldehyde, which absorbs into the body via the upper respiratory tract and mouth.  Acetaldehyde also gets dissolved into saliva and enters the stomach when it is swallowed.[6]  Once it enters the body, it is broken down by aldehyde dehydrogenase in the blood, liver and elsewhere in the body, including at the blood-brain barrier.[7]

Some studies have shown that naturally occurring polysaccharides in tobacco, like cellulose, are the main sources of acetaldehyde in cigarette smoke.[8]  The amount that enters the body is mostly affected by design factors that increase total smoke production such the kinds of filter and paper used. 

Acetaldehyde from Air Pollution

Acetaldehyde also finds common use in industry.  This can result in varying quantities of it finding its way into waste water and the air that we breath.  Some common sources of acetaldehyde from industry include emissions from power plants, refineries, cement kilns, lumber and wood mills and paper mills.  Aside from industrial sources, another dominant source of acetaldehyde is the smoke from wood burning in residential fire places and the controlled burning of forests and vegetation.[9]

Acetaldehyde is also found in automobile and diesel exhaust fumes, making it prevalent in the air of densely populated cities.

Acetaldehyde from Diet

To further emphasise the prevalence of acetaldehyde in our environment, it is also necessary point out the degree to which this toxin enters our body through the foods and beverages we consume.  Like any toxin, the extent of its deleterious effect on the body is proportional to the regularity of our exposure to it. 

Below is a chart taken from a 2011 study conducted by German researchers that looked at the amount of acetaldehyde exposure we get from various good groups:[10]

Acetaldehyde levels in food and beverages

In this study, some of the foods and beverages containing the highest amount of acetaldehyde included instant coffee and fermented foods such as yogurt.

Acetaldehyde is a by-product of the fermentation process, thus most fermented foods and beverages such as yogurt, kimchi, sauerkraut, natto and kombucha, will contain elevated levels of acetaldehyde. 

In most cases, the fermentation of the foods and beverages we consume occurs outside of the body.  However, in the case of sugars, it is common for fermentation to occur inside of our digestive system (by a yeast called Candida Albicans).  In this case, the amount of acetaldehyde exposure can depend on the amount of sugar consumed and the prevalence of Candida Albicans in an individual’s internal bacterial ecosystem.[11]

Why is a Failure to Break Down Acetaldehyde Toxic for the Body?

As evidenced above, acetaldehyde can make its way into the body from a plethora of different sources in our environment.  As alarming as this might sound, it is necessary to preface this with the notion that it is not exposure per se that is harmful, but rather the scale and regularity of this exposure.

The higher the quantity of acetaldehyde that enters the system, the harder it will be for the body to adequately break it down into a non-toxic and readily excretable form.  Similarly, the regularity of this exposure will also be relevant in terms of how well the body can catalyze its various defenses to neutralize the toxin.

In cases where the body is unable to adequately break down acetaldehyde into a non-harmful and readily excretable form (i.e. due to ALDH2 deficiency), the toxin can enter the blood and cause various health complications.

DNA Damage

In a recent 2018 study conducted by researchers from the MRC Laboratory of Molecular Biology at Cambridge, researchers confirmed a link between acetaldehyde and damage to DNA in blood stem cells.  They also found that some subjects (i.e. those with ALDH2 deficiency) were subject to 4 times more DNA damage than subjects without the deficiency.[12]

Cancer Risks

The International Agency for Research on Cancer and the US National Institutes of Health have both issued strong warnings of the carcinogenic effect of acetaldehyde on humans and the heightened risk that exist for ALDH2 deficient individuals.[13][14]

The body of research around acetaldehyde and its links to various cancers is abundant.

Some examples include cancers of the:

Mental Impairment

Some researchers have also suggested that acetaldehyde exposure can lead to some of the behavioral and physiological effects previously attributed to alcohol, such as a reduction in coordination, memory impairment and tiredness.[20]  Whilst research on this matter is contested and somewhat inconclusive, the findings remain pertinent in terms of the possible day to day effects of having too much exposure to the toxin.

Are Some People at More Risk Than Others?

The risks of acetaldehyde exposure discussed above apply to everyone.  However, the degree to which they apply can vary from person to person depending on the efficiency with which their body is able to break down acetaldehyde into a non-toxic and easily excretable form.  As discussed earlier in the article, the way in which our bodies do this is via a process called aldehyde dehydrogenase.

As discussed in our article about ALDH2 deficiency, some individuals possess a mutated gene that causes a deficiency in their ability to break down acetaldehyde.  Whilst genetic testing is the most accurate and only truly reliable way to determine whether someone is affected by this mutation, one indication is if someone suffers a red face when they get alcohol.

This red face from alcohol is a histamine reaction to the acetaldehyde that was not broken down into a non-toxic and easily excretable form.  Individuals who get this can be said to most likely possess the gene mutation that causes the body to be bad at breaking down acetaldehyde and thus would be more at risk in terms of the health risks discussed above.

Read more about this in our article about ALDH2 deficiency.

How to Help the Body Break Down Acetaldehyde

Now we will discuss various ways that are commonly being used to help the body break down acetaldehyde and minimise the various health risks discussed above. 

Reduce Acetaldehyde Exposure

The body can be aided significantly by reducing the amount of acetaldehyde it is required to break down at any given time.  For example, many alcoholic beverages, such as white wine, are known to contain large amounts of acetaldehyde.  When combining the acetaldehyde from the wine with the acetaldehyde that is produced during the metabolism of the wine’s alcohol, the result is a heavy load of toxins that the body is required to break down. 

Couple this with an ALDH2 deficient liver and we have a situation where a large dose of acetaldehyde begins to contribute to some of the health risks discussed above.  Moreover, if we increase the quantity to 3 glasses of wine instead 1 and increase the regularity of the exposure to 3 times a week, the risks begin to multiply very quickly.

The same logic applies to the various other environmental sources of acetaldehyde discussed in this article.  The amount and regularity of exposure to the various sources of acetaldehyde in the environment will directly affect the severity of the risks discussed.

Therefore, becoming more conscious of the sources of acetaldehyde and reducing exposure to these sources can help the body break down acetaldehyde by reducing the amount it has it break down and, importantly, the amount that slips through the cracks and makes it into the blood.

Glutathione

Glutathione is a tripeptide made up of three amino acids (cysteine, glutamic acid, and glycine).  It is present in most mammalian tissue and acts as an antioxidant, scavenger of free radicals and a powerful detoxifying agent.[21] The cysteine component of glutathione has been shown to reduce acetaldehyde in the stomach after alcohol consumption.[22]

Glutathione is produced naturally by the human body, however is depleted rapidly when alcohol is consumed.[23] Boosting glutathione levels prior to and after alcohol consumption may work to counteract this depletion and restore the body’s ability to naturally break down acetaldehyde before it reaches the blood.

Unfortunately, glutathione supplementation is problematic in terms of its bioavailability when taken orally.

NAC

NAC, or N-Acetyl-Cysteine, is an amino acid that breaks down quickly into Glutathione and is also a prerequisite co-factor for the body’s natural production of glutathione.  Unlike glutathione supplementation, NAC supplementation is more bio-available and a more effective way to increase the body’s natural glutathione levels than direct supplementation of glutathione itself.

NAC has also been studied in combination with alcohol.  Results show that, in addition to helping increase the body’s natural production of glutathione, NAC also bind directly to acetaldehyde in the stomach before it can make its way into the blood stream.[24]

Quercetin

Quercetin is a flavonol found in many grains, leaves, vegetables and fruits.  Studies have shown that quercetin supplementation has can increase intracellular concentration of glutathione by approximately 50%.[25]  As mentioned above, increasing the body’s glutathione levels can help break down acetaldehyde.

L-Theanine

L-theanine is an amino acid found in green tea.  Japanese researchers have extensively studied the interaction of L-Theanine and alcohol.  They found it to increase glutathione in the body by increasing the level of glutamate in the liver.[26]  Increased glutathione levels allow the body to break down acetaldehyde more quickly and helps reverse the depletion of glutathione caused by alcohol consumption.

Sunset

Sunset is a supplement that combines NAC, Quercetin and L-Theanine to help the body break down acetaldehyde from alcohol and other environmental sources.  The three ingredients are combined with other complimentary compounds to form a synergy that is more effective than the sum of its parts.



References

[1] https://www.ncbi.nlm.nih.gov/mesh/68000079

[2] https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C44328

[3] http://www.hmdb.ca/metabolites/HMDB0000990

[4] https://www.sciencedirect.com/science/article/pii/B9780080468846004061

[5] https://pubs.niaaa.nih.gov/publications/aa72/aa72.htm

[6] https://www.ncbi.nlm.nih.gov/pubmed/17590988

[7] https://www.ncbi.nlm.nih.gov/pubmed/12437324

[8] https://doi.org/10.1080/08958370304461

[9] http://www.npi.gov.au/resource/acetaldehyde

[10] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124883/

[11] https://doi.org/10.1002/ijc.25844

[12] https://www.nature.com/articles/nature25154

[13] https://www.iarc.fr/en/media-centre/pr/2009/pdfs/pr196_E.pdf

[14] https://www.nih.gov/news-events/news-releases/alcohol-flush-signals-increased-cancer-risk-among-east-asians

[15] https://www.ncbi.nlm.nih.gov/pubmed/19190158

[16] https://www.ncbi.nlm.nih.gov/pubmed/16103445

[17] http://www.ncbi.nlm.nih.gov/pubmed/23101985

[18] http://www.ncbi.nlm.nih.gov/pubmed/12439712

[19] http://www.ncbi.nlm.nih.gov/pubmed/21307158

[20] https://pubs.niaaa.nih.gov/publications/arh294/258-265.pdf

[21] https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C523

[22] https://www.ncbi.nlm.nih.gov/pubmed/21143248

[23] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1930162/

[24] https://www.ncbi.nlm.nih.gov/pubmed/8833231

[25] https://www.sciencedirect.com/science/article/pii/S0891584901008127

[26] https://www.ncbi.nlm.nih.gov/pubmed/16141543

 

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Jordana Lee profile picture Written by - Asian flush consultant @ SRQ Labs

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